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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of 4 week old BALB/c_Fech m1Pas mice (Fech) vs with 4 week old control BALB/c mice

ABSTRACT: Comparison of liver gene expression of 4 week old BALB/c_Fech m1Pas mice(Fech mice for short) with 4 week old control BALB/c mice.

ORGANISM(S): Mus musculus

DISEASE(S): porphyria NOS

SUBMITTER: Reginald Davies

PROVIDER: E-MEXP-194 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Hepatic gene expression in protoporphyic Fech mice is associated with cholestatic injury but not a marked depletion of the heme regulatory pool.

Davies Reginald R Schuurman Arenda A Barker Colin R CR Clothier Bruce B Chernova Tatyana T Higginson Fiona M FM Judah David J DJ Dinsdale David D Edwards Richard E RE Greaves Peter P Gant Timothy W TW Smith Andrew G AG

The American journal of pathology 20050401 4

BALB/c Fech(m1Pas) mice have a mutated ferrochelatase gene resulting in protoporphyria that models the hepatic injury occurring sporadically in human erythropoietic protoporphyria. We used this mouse model to study the development of the injury and to compare the dysfunction of heme synthesis with hepatic gene expression of liver metabolism, oxidative stress, and cellular injury/inflammation. From an early age expression of total cytochrome P450 and many of its isoforms was significantly lower t ...[more]

PMID: 15793285

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