Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): AIDS-KS, HIV+, nodular (late) stage
SUBMITTER: Stephen Henderson
PROVIDER: E-MEXP-66 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature genetics 20040627 7
The biology of Kaposi sarcoma is poorly understood because the dominant cell type in Kaposi sarcoma lesions is not known. We show by gene expression microarrays that neoplastic cells of Kaposi sarcoma are closely related to lymphatic endothelial cells (LECs) and that Kaposi sarcoma herpesvirus (KSHV) infects both LECs and blood vascular endothelial cells (BECs) in vitro. The gene expression microarray profiles of infected LECs and BECs show that KSHV induces transcriptional reprogramming of both ...[more]