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Transcription profiling of Kaposi sarcoma, normal skin and primary cells

ABSTRACT: Identification of the relationships of Kaposi sarcoma (KS), normal skin to various cell cultures. The effects of KS herpes virus, the infectious cause of KS, on infected endothelial cells are also investigated.

ORGANISM(S): Homo sapiens

DISEASE(S): AIDS-KS, HIV+, nodular (late) stage

SUBMITTER: Stephen Henderson

PROVIDER: E-MEXP-66 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.

Wang Hsei-Wei HW Trotter Matthew W B MW Lagos Dimitrios D Bourboulia Dimitra D Henderson Stephen S Mäkinen Taija T Elliman Stephen S Flanagan Adrienne M AM Alitalo Kari K Boshoff Chris C

Nature genetics 20040627 7

The biology of Kaposi sarcoma is poorly understood because the dominant cell type in Kaposi sarcoma lesions is not known. We show by gene expression microarrays that neoplastic cells of Kaposi sarcoma are closely related to lymphatic endothelial cells (LECs) and that Kaposi sarcoma herpesvirus (KSHV) infects both LECs and blood vascular endothelial cells (BECs) in vitro. The gene expression microarray profiles of infected LECs and BECs show that KSHV induces transcriptional reprogramming of both ...[more]

PMID: 15220918

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