Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): infiltrating ductal carcinoma
SUBMITTER: Bernard Futscher
PROVIDER: E-MEXP-882 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Novak Petr P Jensen Taylor T Oshiro Marc M MM Wozniak Ryan J RJ Nouzova Marcella M Watts George S GS Klimecki Walter T WT Kim Christina C Futscher Bernard W BW
Cancer research 20061106 22
Using an integrated approach of epigenomic scanning and gene expression profiling, we found aberrant methylation and epigenetic silencing of a small neighborhood of contiguous genes-the HOXA gene cluster in human breast cancer. The observed transcriptional repression was localized to approximately 100 kb of the HOXA gene cluster and did not extend to genes located upstream or downstream of the cluster. Bisulfite sequencing, chromatin immunoprecipitation, and quantitative reverse transcription-PC ...[more]