MRNA Sequencing of STG in schizophrenia
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Xi Wang
PROVIDER: E-MTAB-1030 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia.
Wu Jing Qin JQ Wang Xi X Beveridge Natalie J NJ Tooney Paul A PA Scott Rodney J RJ Carr Vaughan J VJ Cairns Murray J MJ
PloS one 20120427 4
<h4>Background</h4>While hybridization based analysis of the cortical transcriptome has provided important insight into the neuropathology of schizophrenia, it represents a restricted view of disease-associated gene activity based on predetermined probes. By contrast, sequencing technology can provide un-biased analysis of transcription at nucleotide resolution. Here we use this approach to investigate schizophrenia-associated cortical gene expression.<h4>Methodology/principal findings</h4>The d ...[more]
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