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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of rat bladder after inoculation with bladder cancer cells

ABSTRACT: Rat bladder cancer cells (AY-27 cell line) were inoculated intravesically into syngeneic female Fischer rats. The bladder was analyzed by histology and Affymetrix GeneChips and compared to bladders from sham operated and normal rats.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Endre Anderssen

PROVIDER: E-MTAB-104 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling and pathway analysis of superficial bladder cancer in rats.

Arum Carl-Jørgen CJ Anderssen Endre E Tømmerås Karin K Lundgren Steiner S Chen Duan D Zhao Chun-Mei CM

Urology 20090803 3

<h4>Objectives</h4>To reveal the gene expression profile and pathways involved in host-tumor interactions in a rat orthotopic syngeneic bladder cancer model.<h4>Methods</h4>Rat bladder cancer cells (AY-27 cell line) were inoculated intravesically into female Fischer rats. The bladders were analyzed at 7, 14, and 28 days by histologic examination and at 14 days with Affymetrix GeneChip with a newly developed bioinformatics program for the Kyoto Encyclopedia of Genes and Genomes (KEGG).<h4>Results ...[more]

PMID: 19647301

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