Ontology highlight
ABSTRACT:
INSTRUMENT(S): NextSeq 500
ORGANISM(S): Homo sapiens
SUBMITTER: Ben Towler
PROVIDER: E-MTAB-10808 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Pashler Amy L AL Towler Benjamin P BP Jones Christopher I CI Haime Hope J HJ Burgess Tom T Newbury Sarah F SF
RNA (New York, N.Y.) 20210715 10
XRN1 is a highly conserved exoribonuclease which degrades uncapped RNAs in a 5'-3' direction. Degradation of RNAs by XRN1 is important in many cellular and developmental processes and is relevant to human disease. Studies in <i>D. melanogaster</i> demonstrate that XRN1 can target specific RNAs, which have important consequences for developmental pathways. Osteosarcoma is a malignancy of the bone and accounts for 2% of all pediatric cancers worldwide. Five-year survival of patients has remained s ...[more]