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Genome-wide copy number variation analysis of congenital kidney anomalies

ABSTRACT: To identify novel genetic causes of congenital kidney anomalies(KA), we performed a whole genome copy number variation (CNV) detection in 62 patients with KA using Agilent SurePrint G3 Human CGH Microarray Kit (1x1M). Agilent sex-matched human DNA was used as reference. Data were extracted using Agilent Feature Extraction software v10.7 and CNVs were called using the ADM-II algorithm with a threshold of 6.0 in Agilent CytoGenomics software v5.0. With a systematic analysis, we identified 10 known or novel genomic imbalances in 9 (14.5%) cases.

ORGANISM(S): Homo sapiens

SUBMITTER: Huihui Du

PROVIDER: E-MTAB-11153 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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