Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

30 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of cerebellar tissues of control and prion-inoculated mice

ABSTRACT: We carried out RNA-seq of cerebellar tissues of control and prion-inoculated BL6 mice at two time points: 56 days post-inoculation (early disease) and 182 days post-inoculation (terminal disease).

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Yingjun Liu

PROVIDER: E-MTAB-11742 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

RNA-Seq of control and prion-exposed mouse cerebellar slice cultures treated with or without FabPOM2

Project description:We carried out time-course RNA-Seq in control and prion-exposed BL6 organotypic cerebellar slices treated with or without FabPOM2.

2022-04-20 | E-MTAB-11635 | biostudies-arrayexpress

Efficacy and molecular mechanism of a glycoside compound inhibiting abnormal prion protein formation in prion-infected cells

Project description:This report describes our study of the efficacy and the potential mechanism underlying the anti-prion action of a new anti-prion compound having a glycoside structure in prion-infected cells. The study revealed involvements of two factors in the mechanism of the compound action: interferon and a microtubule nucleation activator, phosphodiesterase 4D interacting protein. In particular, phosphodiesterase 4D interacting protein was suggested to be important in regulating the trafficking or fusion of prion protein-containing vesicles or structures in cells. The findings of the study are expected to be useful not only for the elucidation of cellular regulatory mechanisms of prion protein, but also for the implication of new targets for therapeutic development. Prion-infected N167 cells were treated with either anti-prion glycoside compound (Gly-9) or control glycoside compound (Gly-14) at a dose of 5 M-NM-<g/mL for three days. Then, gene expression profiles were analyzed by DNA microarray analysis. Experiments were performed in quadruplicate.

2014-02-22 | E-GEOD-55241 | biostudies-arrayexpress

GPI-glycan structures of human Prion (M232R) from knock-in mice_LC-MSMS

Project description:To determine glycosylphosphatidylinositol (GPI) structures of human prion proteins with M232R mutation isolated from knock-in mice those express human prion protein instead of mouse one.

2023-03-08 | PXD037584 | Pride

GPI-glycan structures of human Prion from knock-in mice_LC-MSMS

Project description:To determine glycosylphosphatidylinositol (GPI) structures of human prion proteins isolated from knock-in mice those express human prion protein instead of mouse one.

2020-04-22 | PXD017655 | Pride

GPI-glycan structures of Prion from WT mouse brains

Project description:To determine glycosylphosphatidylinositol (GPI) structures of prion proteins isolated from mouse brains.

2022-04-04 | PXD029190 | Pride

GPI-glycan structures of Prion from PGAP4-KO mouse brains

Project description:To determine glycosylphosphatidylinositol (GPI) structures of prion proteins isolated from PGAP4-KO mouse brains.

2022-04-04 | PXD029189 | Pride

GPI-glycan structures of human Prion from a human brain

Project description:To determine glycosylphosphatidylinositol (GPI) structures of human prion proteins isolated from a human brain.

2020-04-22 | PXD017656 | Pride

Transcription profiling of mouse brain infected with prions in eight mouse-prion strain combinations in a systems approach to the study of prion disease

Project description:Prions cause transmissible neurodegenerative diseases and replicate by conformational conversion of normal, benign forms of prion protein (PrPC) to disease-causing PrPSc isoforms. A systems approach to disease postulates that disease arises from the pathological perturbation (genetic and/or environmental) of one or more biological networks in the relevant organ. In this regard, we tracked global (all mRNA transcripts) gene expression in the brains of eight distinct mouse strain-prion strain combinations at 8 - 10 time points throughout the progression of the disease to capture the effects of prion strain, host genetics, and PrP concentration on disease incubation time. Data are also available from http://prion.systemsbiology.net

2009-03-25 | E-MTAB-76 | biostudies-arrayexpress

MicroRNA alterations in a mouse model of prion disease

Project description:MicroRNA alterations were investigated in a Tg501 mouse model of prion disases that express the goat prion protein (PRNP). Age-matched Tg501 mice without inoculation (controls) and intracranially inoculated with caprine scrapie strain were compared in presymptomatic and symptomatic stages.

2020-06-17 | GSE146013 | GEO