Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Tetsuya Hirata
LAB HEAD: Taroh Kinoshita
PROVIDER: PXD017655 | Pride | 2020-04-22
REPOSITORIES: Pride
Items per page: 1 - 5 of 6 |
The Journal of biological chemistry 20200422 22
Prion diseases are transmissible, lethal neurodegenerative disorders caused by accumulation of the aggregated scrapie form of the prion protein (PrP<sup>Sc</sup>) after conversion of the cellular prion protein (PrP<sup>C</sup>). The glycosylphosphatidylinositol (GPI) anchor of PrP<sup>C</sup> is involved in prion disease pathogenesis, and especially sialic acid in a GPI side chain reportedly affects PrP<sup>C</sup> conversion. Thus, it is important to define the location and structure of the GPI ...[more]