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FHOD1 in EMT

ABSTRACT: Comparison of gene expression in oral squamous carcinoma cells of epithelial and mesenchymal type

ORGANISM(S): Homo sapiens

SUBMITTER: Maria Gardberg

PROVIDER: E-MTAB-1420 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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FHOD1, a formin upregulated in epithelial-mesenchymal transition, participates in cancer cell migration and invasion.

Gardberg Maria M Kaipio Katja K Lehtinen Laura L Mikkonen Piia P Heuser Vanina D VD Talvinen Kati K Iljin Kristiina K Kampf Caroline C Uhlen Mathias M Grénman Reidar R Koivisto Mari M Carpén Olli O

PloS one 20130926 9

Cancer cells can obtain their ability to invade and metastasise by undergoing epithelial-to-mesenchymal transition (EMT). Exploiting this mechanism of cellular plasticity, malignant cells can remodel their actin cytoskeleton and down-regulate proteins needed for cell-cell contacts. The mechanisms of cytoskeletal reorganisation resulting in mesenchymal morphology and increased invasive potential are poorly understood. Actin nucleating formins have been implicated as key players in EMT. Here, we a ...[more]

PMID: 24086398

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