Project description:U-2 OS (human osteosarcoma cell line) were treated with ZM447439 (an aurora kinase inhibitor), SB202190 (a p38 inhibitor) or ZM447439+SB202190 and resulting changes in gene expression were profiled.
Project description:Transcriptional profiling of e8.5 mouse embryos comparing wt with Srd5a3Gt(betaGeo)703Lex/Gt(betaGeo)703Lex. Goal was to determine the developmental pathway disrupted in the mutant.<br>
Project description:Microarray analyses of WPMY-1 <br><br>cells, either untreated (solvent) or treated with <br><br>GW501516 (0.3 µM), TGFBeta2 (10 ng/ml), or <br><br>both ligands for 6 h.
Project description:Diploid human lung fibroblasts (WI-38 cells) were exposed to TGFbeta2 (inducing myofibroblast differentiation), GW501516 (a PPARbetadelta agonist) or both. Treated and control samples were hybridized against a reference sample made up of all samples pooled in equal parts and diluted by the number of samples.
Project description:SW620 were transfected with siMYC or siCTR at time point 0h. 24h later cells were splitter 1:2, additional 24 h later (48h after transfection) cells were treated with BEZ235 (200nM) or DMSO. Cells were harvested after additional 24h (72h after siRNA transfection; 24h BEZ235 treatment.