Dataset Information
Expression profiling, MDA-MB-231-luc2 response to GW501516
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo_sapiens
SUBMITTER: Florian Finkernagel
PROVIDER: E-MTAB-1262 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion.
Oncogene 20121203 44
Besides its established functions in intermediary metabolism and developmental processes, the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) has a less defined role in tumorigenesis. In the present study, we have identified a function for PPARβ/δ in cancer cell invasion. We show that two structurally divergent inhibitory ligands for PPARβ/δ, the inverse agonists ST247 and DG172, strongly inhibit the serum- and transforming growth factor β (TGFβ)-induced invasion of MDA ...[more]
