Unknown,Transcriptomics,Genomics,Proteomics

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Expression profiling, MDA-MB-231-luc2 response to GW501516


ABSTRACT: MDA-MB-231-luc2 cells were treated with the PPARd specific agonist GW501516 and the resulting expression changes profiled.

ORGANISM(S): Homo_sapiens

SUBMITTER: Florian Finkernagel 

PROVIDER: E-MTAB-1262 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Besides its established functions in intermediary metabolism and developmental processes, the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) has a less defined role in tumorigenesis. In the present study, we have identified a function for PPARβ/δ in cancer cell invasion. We show that two structurally divergent inhibitory ligands for PPARβ/δ, the inverse agonists ST247 and DG172, strongly inhibit the serum- and transforming growth factor β (TGFβ)-induced invasion of MDA  ...[more]

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