Dataset Information
Transcription profiling by array of human WPMY-1 cells treated with GW501516 ((a PPARbetadelta agonist) or TFGBeta2
Ontology highlight
ABSTRACT:
cells, either untreated (solvent) or treated with
GW501516 (0.3 µM), TGFBeta2 (10 ng/ml), or
both ligands for 6 h.
ORGANISM(S): Homo sapiens
SUBMITTER: Florian Finkernagel
PROVIDER: E-MEXP-2748 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcriptional profiling identifies functional interactions of TGF β and PPAR β/δ signaling: synergistic induction of ANGPTL4 transcription.
The Journal of biological chemistry 20100701 38
Peroxisome proliferator-activated receptors (PPARs) not only play a key role in regulating metabolic pathways but also modulate inflammatory processes, pointing to a functional interaction between PPAR and cytokine signaling pathways. In this study, we show by genome-wide transcriptional profiling that PPARβ/δ and transforming growth factor-β (TGFβ) pathways functionally interact in human myofibroblasts and that a subset of these genes is cooperatively activated by TGFβ and PPARβ/δ. Using the an ...[more]
