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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of mouse Cdx2 knock out intestinal epithelium

ABSTRACT: RNAs were extracted from E18.5 control and Cdx2/villin-cre mutant ileums. We aim to identify the gene network changes in the mutant epithelia. We are especially interested in genes related with proliferation, apoptosis and cell differentiation.

ORGANISM(S): Mus musculus

SUBMITTER: Jonathan Schug

PROVIDER: E-MTAB-218 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cdx2 regulates endo-lysosomal function and epithelial cell polarity.

Gao Nan N Kaestner Klaus H KH

Genes & development 20100601 12

In contrast to our significant understanding of signaling cascades that determine cell polarity in lower eukaryotic or immortalized cells, little is known about the transcriptional program that governs mammalian epithelial polarization in vivo. Here we show, using conditional gene ablation and three-dimensional tissue culture, that the homeobox transcription factor Cdx2 controls apical-basolateral polarity in mouse enterocytes and human colonic epithelial cells. Cdx2 regulates a comprehensive ge ...[more]

PMID: 20551175

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