Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Stephan Tenbaum
PROVIDER: E-MTAB-2446 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Arqués Oriol O Chicote Irene I Puig Isabel I Tenbaum Stephan P SP Argilés Guillem G Dienstmann Rodrigo R Fernández Natalia N Caratù Ginevra G Matito Judit J Silberschmidt Daniel D Rodon Jordi J Landolfi Stefania S Prat Aleix A Espín Eloy E Charco Ramón R Nuciforo Paolo P Vivancos Ana A Shao Wenlin W Tabernero Josep J Palmer Héctor G HG
Clinical cancer research : an official journal of the American Association for Cancer Research 20150729 3
<h4>Purpose</h4>Oncogenic mutations in the KRAS/PI3K/AKT pathway are one of the most frequent alterations in cancer. Although PI3K or AKT inhibitors show promising results in clinical trials, drug resistance frequently emerges. We previously revealed Wnt/β-catenin signaling hyperactivation as responsible for such resistance in colorectal cancer. Here we investigate Wnt-mediated resistance in patients treated with PI3K or AKT inhibitors in clinical trials and evaluate the efficacy of a new Wnt/ta ...[more]