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Mapping mitochondrial DNA recombination in yeast


ABSTRACT: In this study, we present the first genome-wide recombination map for mitochondrial DNA in yeast. We also assess the impact of the genetic background and of several gene deletions on the recombination profiles.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Charles Girardot 

PROVIDER: E-MTAB-2474 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A genome-wide map of mitochondrial DNA recombination in yeast.

Fritsch Emilie S ES   Chabbert Christophe D CD   Klaus Bernd B   Steinmetz Lars M LM  

Genetics 20140731 2


In eukaryotic cells, the production of cellular energy requires close interplay between nuclear and mitochondrial genomes. The mitochondrial genome is essential in that it encodes several genes involved in oxidative phosphorylation. Each cell contains several mitochondrial genome copies and mitochondrial DNA recombination is a widespread process occurring in plants, fungi, protists, and invertebrates. Saccharomyces cerevisiae has proved to be an excellent model to dissect mitochondrial biology.  ...[more]

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