Dataset Information
Transcription profiling by array of human embryonic stem cells differentiated towards an endodermal fate compared to clones subjected to EOMES knockdown via shRNA
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Matthew Trotter
PROVIDER: E-MTAB-351 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Pluripotency factors regulate definitive endoderm specification through eomesodermin.
Genes & development 20110118 3
Understanding the molecular mechanisms controlling early cell fate decisions in mammals is a major objective toward the development of robust methods for the differentiation of human pluripotent stem cells into clinically relevant cell types. Here, we used human embryonic stem cells and mouse epiblast stem cells to study specification of definitive endoderm in vitro. Using a combination of whole-genome expression and chromatin immunoprecipitation (ChIP) deep sequencing (ChIP-seq) analyses, we es ...[more]
