Dataset Information
Transcription profiling by array of mouse jejunum cells of FVB/N wild type and Lrig1 knockout littermates
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Matthew Trotter
PROVIDER: E-MTAB-378 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.
Nature cell biology 20120304 4
Maintenance of adult tissues is carried out by stem cells and is sustained throughout life in a highly ordered manner. Homeostasis within the stem-cell compartment is governed by positive- and negative-feedback regulation of instructive extrinsic and intrinsic signals. ErbB signalling is a prerequisite for maintenance of the intestinal epithelium following injury and tumour formation. As ErbB-family ligands and receptors are highly expressed within the stem-cell niche, we hypothesize that strong ...[more]
