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Transcription profiling of fission yeast to investigate the role of the TORC2 complex in gene expression, DNA metabolism and damage response

ABSTRACT: Investigating the role of TORC2 complex in gene expression, DNA meatbolism and DNA damage response

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Ronit Weisman

PROVIDER: E-MTAB-39 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.

Schonbrun Miriam M Laor Dana D López-Maury Luis L Bähler Jürg J Kupiec Martin M Weisman Ronit R

Molecular and cellular biology 20090622 16

The Target Of Rapamycin (TOR) kinase belongs to the highly conserved eukaryotic family of phosphatidylinositol-3-kinase-related kinases (PIKKs). TOR proteins are found at the core of two distinct evolutionarily conserved complexes, TORC1 and TORC2. Disruption of TORC1 or TORC2 results in characteristically dissimilar phenotypes. TORC1 is a major cell growth regulator, while the cellular roles of TORC2 are not well understood. In the fission yeast Schizosaccharomyces pombe, Tor1 is a component of ...[more]

PMID: 19546237

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