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Genome-wide microRNA expression status of non-B non-C hepatocellular carcinoma assessed by 3D-Gene Human miRNA Oligo Chip (Toray, Japan)

ABSTRACT: Genome-wide microRNA expression analysis for clinical samples from patients in whom non-B non-C hepatocellular carcinoma developed. A pair of tissues (N=24 pairs) from non-tumor background and tumor was provided from every patient. A platform for this experiment was 3D-Gene Human miRNA Oligo Chip (Toray, Japan).

ORGANISM(S): Homo sapiens

SUBMITTER: Masanori Nojima

PROVIDER: E-MTAB-4170 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global, cancer-specific microRNA cluster hypomethylation was functionally associated with the development of non-B non-C hepatocellular carcinoma.

Nojima Masanori M Matsui Takeshi T Tamori Akihiro A Kubo Shoji S Shirabe Ken K Kimura Koichi K Shimada Mitsuo M Utsunomiya Tohru T Kondo Yasuteru Y Iio Etsuko E Naito Yutaka Y Ochiya Takahiro T Tanaka Yasuhito Y

Molecular cancer 20160430 1

<h4>Background</h4>While hepatitis B and C viral infection have been suppressed, non-B non-C hepatocellular carcinoma (NBNC-HCC) is considered to be rising in incidence terms in some developed countries where prevalence of those viral infections among HCC patients had been very high (such as Japan, Korea, and Italy). To elucidate critical molecular changes in NBNC-HCC, we integrated three large datasets relating to comprehensive array-based analysis of genome-wide DNA methylation (N = 43 pairs) ...[more]

PMID: 27137948

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