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Transcriptional profiling of pancreatic beta cells from wild type and Abcc8 knock-out mice

ABSTRACT: Abcc8 (sulfonylurea receptor 1, SUR1) is an essential part of the ATP-sensitive potassium channel necessary for coupling energy metabolism and membrane potential. In this study we assessed the impact of eliminating Abcc8 on islet morphology, beta-cell identity, and gene expression. Beta cells were isolated by FACS from 60 day old mice based on expression of a MIP-GFP transgene.

INSTRUMENT(S): NextSeq 500, All computation performed on the Vanderbilt ACCRE cluster.

ORGANISM(S): Mus musculus

SUBMITTER: Jean-Philippe Cartailler

PROVIDER: E-MTAB-4726 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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