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Genes affected by manipulation of LIMT, a novel metastasis inhibiting lncRNA is suppressed by EGF and down-regulated in aggressive breast cancer

ABSTRACT: The long non coding RNA LIMT was found in our study to inhibit cellular migration in vitro and to inhibit colonization of mammary tumorigenic cells in lungs of mice in vivo. In order to uncover the mechanism enabling these tumor suppressive functions of LIMT the expression of this lncRNA was knocked down (by siRNA) or overexpressed in MCF10A cells and RNA level of genes was measured using Affymetrix gene expression arrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Aldema Sas-Chen

PROVIDER: E-MTAB-4821 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer.

Sas-Chen Aldema A Aure Miriam R MR Leibovich Limor L Carvalho Silvia S Enuka Yehoshua Y Körner Cindy C Polycarpou-Schwarz Maria M Lavi Sara S Nevo Nava N Kuznetsov Yuri Y Yuan Justin J Azuaje Francisco F Ulitsky Igor I Diederichs Sven S Wiemann Stefan S Yakhini Zohar Z Kristensen Vessela N VN Børresen-Dale Anne-Lise AL Yarden Yosef Y

EMBO molecular medicine 20160901 9

Long noncoding RNAs (lncRNAs) are emerging as regulators of gene expression in pathogenesis, including cancer. Recently, lncRNAs have been implicated in progression of specific subtypes of breast cancer. One aggressive, basal-like subtype associates with increased EGFR signaling, while another, the HER2-enriched subtype, engages a kin of EGFR Based on the premise that EGFR-regulated lncRNAs might control the aggressiveness of basal-like tumors, we identified multiple EGFR-inducible lncRNAs in ba ...[more]

PMID: 27485121

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