Dataset Information
Compare gene expression profile of bone-marrow derived dendritic cells from wild-type and miR155 knockout mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
DISEASE(S): normal
SUBMITTER: Walter Reith
PROVIDER: E-MTAB-497 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function.
Blood 20110308 17
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate target mRNAs by binding to their 3' untranslated regions. There is growing evidence that microRNA-155 (miR155) modulates gene expression in various cell types of the immune system and is a prominent player in the regulation of innate and adaptive immune responses. To define the role of miR155 in dendritic cells (DCs) we performed a detailed analysis of its expression and function in human and mouse DCs. A strong increase in miR155 expres ...[more]
