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Transcription profiling of yeast mutants to determine gene regulation by sterol and sphingolipid composition


ABSTRACT: determination of gene regulation by sterol and sphingolipid composition

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Howard Riezman 

PROVIDER: E-TABM-544 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Sterols and sphingolipids are limited to eukaryotic cells, and their interaction has been proposed to favor formation of lipid microdomains. Although there is abundant biophysical evidence demonstrating their interaction in simple systems, convincing evidence is lacking to show that they function together in cells. Using lipid analysis by mass spectrometry and a genetic approach on mutants in sterol metabolism, we show that cells adjust their membrane composition in response to mutant sterol str  ...[more]

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