Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling by array of 4T1 murine breast carcinoma cells and derived cell lines resistant to photodynamic therapy induced by novel porphyrin-based photosensitizers and temoporfin

ABSTRACT: The efficacy of photodynamic therapy for treating premalignant and malignant tumors is often limited by the emerging resistant tumor cells. We have developed experimental model systems to study the mechanisms associated with resistance to photodynamic therapy induced by structurally similar photosensitizers (two novel porphyrin-based photosensitizers and temoporfin) in mouse mammary carcinoma cell line 4T1. Photodynamic therapy resistant clones were obtained in vitro by exposure to constant photosensitizer concentration and irradiation with increasing light doses.

ORGANISM(S): Mus musculus

SUBMITTER: Jarmila Kralova

PROVIDER: E-MTAB-5082 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Glycol porphyrin derivatives and temoporfin elicit resistance to photodynamic therapy by different mechanisms.

Kralova Jarmila J Kolar Michal M Kahle Michal M Truksa Jaroslav J Lettlova Sandra S Balusikova Kamila K Bartunek Petr P

Scientific reports 20170315

The development of drug resistance is a major problem which often occurs during anticancer chemotherapies. Photodynamic therapy (PDT) has been studied as an alternative treatment modality for drug-resistant tumors, however the question of resistance to PDT and potential cross-resistance with chemotherapy has yet to be fully answered. To investigate the mechanism of resistance to PDT, we developed an in vitro experimental model system in a mouse mammary carcinoma cell line 4T1. We used two ethyle ...[more]

PMID: 28295025

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Dataset Information

Transcription profiling by array of 4T1 murine breast carcinoma cells and derived cell lines resistant to photodynamic therapy induced by novel porphyrin-based photosensitizers and temoporfin

Publications

Glycol porphyrin derivatives and temoporfin elicit resistance to photodynamic therapy by different mechanisms.

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