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Ageing-rats-2011

ABSTRACT: The experiment was designed to study the effects of senescence on gene expressions in the kidney cortex. Kidney cortex was harvested from five rats at ten weeks of age and five rats at ninety weeks of age. Both kidneys were used and combined as biological replicates in the final analysis.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Michael Hultström

PROVIDER: E-MTAB-613 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Collagen-binding proteins in age-dependent changes in renal collagen turnover: microarray analysis of mRNA expression.

Hultström Michael M Leh Sabine S Paliege Alexander A Bachmann Sebastian S Skogstrand Trude T Iversen Bjarne M BM

Physiological genomics 20120327 10

Aging is associated with progressive structural and functional deterioration of the kidney. Among the morphological changes associated with renal aging is an accumulation of extracellular matrix (ECM) in the glomeruli and tubuloinsterstitium, which may ultimately lead to the development of renal fibrosis. The mechanisms governing the regulation of ECM metabolism during renal aging are only incompletely defined. We present data from a genome-wide mRNA expression study on renal tissue from 90 wk o ...[more]

PMID: 22454451

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