Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of blood from donors with connective tissue diseases in the Lupus Extended Phenotype Cohort

ABSTRACT: The connective tissue diseases (CTDs) are group of inflammatory disorders with overlapping clinical and serological manifestations. We have undertaken Lupus Extended Phenotype (LEAP) study in of a cohort of adult patients with CTDs, namely systemic lupus erythematosus, Sjogren's syndrome, mixed and undifferentiated CTD, limited and diffuse cutaneous systemic sclerosis and dermatomyositis. RNAseq was undertaken in 12 participants from 4 ‘cohorts’ based on interferon stimulated gene and autoantibodies analyses: 3 ISG positive and anti-Smith positive participants; 3 ISG positive and anti-Smith negative participants; 3 ISG negative and anti-Smith positive participants and 3 ISG negative and anti-Smith negative participants.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Leo Zeef 

PROVIDER: E-MTAB-7080 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles.

Reynolds John A JA   Briggs Tracy A TA   Rice Gillian I GI   Darmalinggam Sathya S   Bondet Vincent V   Bruce Ellen E   Khan Mumtaz M   Haque Sahena S   Chinoy Hector H   Herrick Ariane L AL   McCarthy Eoghan M EM   Zeef Leo L   Hayes Andrew A   Duffy Darragh D   Parker Ben B   Bruce Ian N IN  

Arthritis research & therapy 20190614 1

<h4>Objectives</h4>To investigate the relationships between interferon alpha (IFNα) and the clinical and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) in order to determine whether a distinct subpopulation of patients can be identified.<h4>Methods</h4>We recruited patients with at least 1 SARD clinical feature and at least 1 SARD-related autoantibody from two NHS Trusts in Greater Manchester. A 6-gene interferon-stimulated gene (ISG) score was calculated in  ...[more]

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