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Roles of mRNA decay in liver development

ABSTRACT: mRNA decay machineries play important roles in various biological events. Among them, Cnot deadenylase complex has a critical function to trigger mRNA decay. To understand roles of the complex in liver development, we compare RNA expression between control and Cnot complex-deficient liver.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mus musculus

SUBMITTER: Toru Suzuki

PROVIDER: E-MTAB-7182 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.

Suzuki Toru T Kikuguchi Chisato C Nishijima Saori S Nagashima Takeshi T Takahashi Akinori A Okada Mariko M Yamamoto Tadashi T

Development (Cambridge, England) 20190215 4

Liver development involves dramatic gene expression changes mediated by transcriptional and post-transcriptional control. Here, we show that the Cnot deadenylase complex plays a crucial role in liver functional maturation. The Cnot3 gene encodes an essential subunit of the Cnot complex. Mice lacking Cnot3 in liver have reduced body and liver masses, and they display anemia and severe liver damage. Histological analyses indicate that Cnot3-deficient (Cnot3-/-</i ...[more]

PMID: 30733279

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