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Microarray comparison of whole brain gene expression in new mouse mothers treated systemically with the STS inhibitor 667-Coumate, or vehicle solution

ABSTRACT: Deficiency for the enzyme steroid sulfatase (STS) has been associated with postpartum behavioural phenotypes in mice and humans. Here, we compared whole brain gene expression in new mouse mothers acutely treated (two administrations, 48hrs apart) with the STS inhibitor 667-Coumate (10mg/kg p.o.) or vehicle solution (n=12 per group, 3 biological replicates each comprised of 4 pooled individual hemibrain samples).

ORGANISM(S): Mus musculus

SUBMITTER: William Davies

PROVIDER: E-MTAB-7233 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis.

Humby Trevor T Cross Ellen S ES Messer Lauren L Guerrero Silvia S Davies William W

Psychoneuroendocrinology 20160928

Postpartum psychosis (PP) is a severe psychiatric disorder affecting a small proportion of new mothers shortly after childbirth. The molecular pathophysiology underlying the disorder is currently poorly understood, and there are no amenable animal models for the condition; maternal deficiency for the enzyme steroid sulfatase has been proposed as a potential risk mechanism. Here we show that inhibition of steroid sulfatase with 667-COUMATE (10mg/kg p.o.) in new mouse mothers results in behavioura ...[more]

PMID: 27728876

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