Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional analysis of Enterococcus faecalis V583 in three different growth


ABSTRACT: We have studied the effects of three different growth rate (0.05h (-1), 0.15h (-1) and 0.4h(-1) on the trancriptome of E. faecalis grown under energy limitation in chemostat culture

ORGANISM(S): Enterococcus faecalis

SUBMITTER: Ibrahim Mehmeti 

PROVIDER: E-MTAB-725 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Growth rate-dependent control in Enterococcus faecalis: effects on the transcriptome and proteome, and strong regulation of lactate dehydrogenase.

Mehmeti Ibrahim I   Faergestad Ellen M EM   Bekker Martijn M   Snipen Lars L   Nes Ingolf F IF   Holo Helge H  

Applied and environmental microbiology 20111028 1


Enterococcus faecalis V583 was grown in a glucose-limited chemostat at three different growth rates (0.05, 0.15, and 0.4 h⁻¹). The fermentation pattern changed with growth rate, from a mostly homolactic profile at a high growth rate to a fermentation dominated by formate, acetate, and ethanol production at a low growth rate. A number of amino acids were consumed at the lower growth rates but not by fast-growing cells. The change in metabolic profile was caused mainly by decreased flux through la  ...[more]

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