Unknown,Transcriptomics,Genomics,Proteomics

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Human fetal liver, skin and kidney single cell transcriptome data

ABSTRACT: This is a droplet-based single cell transcriptome data set from 13 human fetal livers (6-18 PCW) and 8 skin and kidney samples (6-12 PCW). It includes 199,642 cells with a mean detected gene number of 3000.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Krzysztof Polanski 

PROVIDER: E-MTAB-7407 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Decoding human fetal liver haematopoiesis.

Popescu Dorin-Mirel DM   Botting Rachel A RA   Stephenson Emily E   Green Kile K   Webb Simone S   Jardine Laura L   Calderbank Emily F EF   Polanski Krzysztof K   Goh Issac I   Efremova Mirjana M   Acres Meghan M   Maunder Daniel D   Vegh Peter P   Gitton Yorick Y   Park Jong-Eun JE   Vento-Tormo Roser R   Miao Zhichao Z   Dixon David D   Rowell Rachel R   McDonald David D   Fletcher James J   Poyner Elizabeth E   Reynolds Gary G   Mather Michael M   Moldovan Corina C   Mamanova Lira L   Greig Frankie F   Young Matthew D MD   Meyer Kerstin B KB   Lisgo Steven S   Bacardit Jaume J   Fuller Andrew A   Millar Ben B   Innes Barbara B   Lindsay Susan S   Stubbington Michael J T MJT   Kowalczyk Monika S MS   Li Bo B   Ashenberg Orr O   Tabaka Marcin M   Dionne Danielle D   Tickle Timothy L TL   Slyper Michal M   Rozenblatt-Rosen Orit O   Filby Andrew A   Carey Peter P   Villani Alexandra-Chloé AC   Roy Anindita A   Regev Aviv A   Chédotal Alain A   Roberts Irene I   Göttgens Berthold B   Behjati Sam S   Laurenti Elisa E   Teichmann Sarah A SA   Haniffa Muzlifah M  

Nature 20191009 7778

Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in humans. Here, using single-cell transcriptome profiling of approximately 140,000 liver and 74,000 skin, kidney and yolk sac cells, we identify the repertoire of human blood and immune cells during development. We infer differentiation trajectories from HSC/MPPs and evaluate the influence of the tissue microenviron  ...[more]

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