Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of wild type and delta-sba1 yeast treated with radicicol to study gene regulation by sba1

ABSTRACT: We wanted to study regulation of gene regulation by sba1 (ortholog of mammalian p23) in yeast. sba1/p23 binds to Hsp90 and acts as a co-chaperone. We have a small molecule, radicicol, an analog of geldanamycin to inhibit the binding of p23 to Hsp90. Consequently, we have analyzed the gene expression profile in 4 conditions, wt, delta-sba1; and when Hsp90 function is impaired, that is, wt and delta-sba1 treated with radicicol.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Didier Picard 

PROVIDER: E-TABM-573 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Detection of changes in gene regulatory patterns, elicited by perturbations of the Hsp90 molecular chaperone complex, by visualizing multiple experiments with an animation.

Echeverría Pablo C PC   Forafonov Fedor F   Pandey Deo P DP   Mühlebach Guillaume G   Picard Didier D  

BioData mining 20110614 1

<h4>Background</h4>To make sense out of gene expression profiles, such analyses must be pushed beyond the mere listing of affected genes. For example, if a group of genes persistently display similar changes in expression levels under particular experimental conditions, and the proteins encoded by these genes interact and function in the same cellular compartments, this could be taken as very strong indicators for co-regulated protein complexes. One of the key requirements is having appropriate  ...[more]

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