Ontology highlight
ABSTRACT:
INSTRUMENT(S): Scanning hardware
ORGANISM(S): Bordetella pertussis
SUBMITTER: Craig Cummings
PROVIDER: E-TABM-29 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cummings C A CA Bootsma H J HJ Relman D A DA Miller J F JF
Journal of bacteriology 20060301 5
The Bordetella master virulence regulatory system, BvgAS, controls a spectrum of gene expression states, including the virulent Bvg(+) phase, the avirulent Bvg(-) phase, and at least one Bvg-intermediate (Bvg(i)) phase. We set out to define the species- and strain-specific features of this regulon based on global gene expression profiling. Rather than functioning as a switch, Bvg controls a remarkable continuum of gene expression states, with hundreds of genes maximally expressed in intermediate ...[more]