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Transcription profiling of 3 Bordetella bronchiseptica strains plus or minus nicotinic acid

ABSTRACT: Three B. bronchiseptica strains were grown at 37 degrees C in media containing or lacking nicotinic acid. Samples were harvested at mid-log phase and gene expression difference between the treated and untreated was measured for each strain.

INSTRUMENT(S): Scanning hardware

ORGANISM(S): Bordetella bronchiseptica

SUBMITTER: Craig Cummings

PROVIDER: E-TABM-27 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Species- and strain-specific control of a complex, flexible regulon by Bordetella BvgAS.

Cummings C A CA Bootsma H J HJ Relman D A DA Miller J F JF

Journal of bacteriology 20060301 5

The Bordetella master virulence regulatory system, BvgAS, controls a spectrum of gene expression states, including the virulent Bvg(+) phase, the avirulent Bvg(-) phase, and at least one Bvg-intermediate (Bvg(i)) phase. We set out to define the species- and strain-specific features of this regulon based on global gene expression profiling. Rather than functioning as a switch, Bvg controls a remarkable continuum of gene expression states, with hundreds of genes maximally expressed in intermediate ...[more]

PMID: 16484188

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