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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse embryonic stem cells populations generated during differentiation in the presence or absence of BMP4

ABSTRACT: Transcription profiling of the cell populations generated during differentiation in presence or absence of BMP4

ORGANISM(S): Mus musculus

SUBMITTER: Nathalie Brouard

PROVIDER: E-TABM-363 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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BMP inhibition stimulates WNT-dependent generation of chondrogenic mesoderm from embryonic stem cells.

Tanaka Makoto M Jokubaitis Vanta V Wood Colin C Wang Yi Y Brouard Nathalie N Pera Martin M Hearn Milton M Simmons Paul P Nakayama Naoki N

Stem cell research 20090721 2-3

WNT and bone morphogenetic protein (BMP) signaling are known to stimulate hemogenesis from pluripotent embryonic stem (ES) cells. However, osteochondrogenic mesoderm was generated effectively when BMP signaling is kept to a low level, while WNT signaling was strongly activated. When mesoderm specification from ES cells was exogenous factor dependent, WNT3a addition supported the generation of cardiomyogenic cells expressing lateral plate/extraembryonic mesoderm genes, and this process involved e ...[more]

PMID: 19700382

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