Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Alex Bruce
PROVIDER: E-TABM-660 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bruce Alexander W AW López-Contreras Andrés J AJ Flicek Paul P Down Thomas A TA Dhami Pawandeep P Dillon Shane C SC Koch Christoph M CM Langford Cordelia F CF Dunham Ian I Andrews Robert M RM Vetrie David D
Genome research 20090428 6
The molecular events that contribute to, and result from, the in vivo binding of transcription factors to their cognate DNA sequence motifs in mammalian genomes are poorly understood. We demonstrate that variations within the DNA sequence motifs that bind the transcriptional repressor REST (NRSF) encode in vivo DNA binding affinity hierarchies that contribute to regulatory function during lineage-specific and developmental programs in fundamental ways. First, canonical sequence motifs for REST f ...[more]