Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC10160370 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Zhang Hanwen H Passang Tenzin T Ravindranathan Sruthi S Bommireddy Ramireddy R Jajja Mohammad Raheel MR Yang Lily L Selvaraj Periasamy P Paulos Chrystal M CM Waller Edmund K EK
Frontiers in immunology 20230421
In the past decades, advances in the use of adoptive cellular therapy to treat cancer have led to unprecedented responses in patients with relapsed/refractory or late-stage malignancies. However, cellular exhaustion and senescence limit the efficacy of FDA-approved T-cell therapies in patients with hematologic malignancies and the widespread application of this approach in treating patients with solid tumors. Investigators are addressing the current obstacles by focusing on the manufacturing pro ...[more]