Ontology highlight
ABSTRACT:
SUBMITTER: Mello JA
PROVIDER: S-EPMC1084056 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Mello Jill A JA Silljé Herman H W HH Roche Daniele M J DM Kirschner Doris B DB Nigg Erich A EA Almouzni Geneviève G
EMBO reports 20020315 4
The efficient assembly of newly replicated and repaired DNA into chromatin is essential for proper genome function. Based on genetic studies in Saccharomyces cerevisiae, the histone chaperone anti-silencing function 1 (Asf1) has been implicated in the DNA repair response. Here, the human homologs are shown to function synergistically with human CAF-1 to assemble nucleosomes during nucleotide excision repair in vitro. Furthermore, we demonstrate that hAsf1 proteins can interact directly with the ...[more]