Ontology highlight
ABSTRACT:
SUBMITTER: Mattiroli F
PROVIDER: S-EPMC5394680 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Mattiroli Francesca F Gu Yajie Y Balsbaugh Jeremy L JL Ahn Natalie G NG Luger Karolin K
Scientific reports 20170418
Nucleosome assembly following DNA replication controls epigenome maintenance and genome integrity. Chromatin assembly factor 1 (CAF-1) is the histone chaperone responsible for histone (H3-H4)<sub>2</sub> deposition following DNA synthesis. Structural and functional details for this chaperone complex and its interaction with histones are slowly emerging. Using hydrogen-deuterium exchange coupled to mass spectrometry, combined with in vitro and in vivo mutagenesis studies, we identified the region ...[more]