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Intracellular Synthesis of Indoles Enabled by Visible-Light Photocatalysis.

ABSTRACT: Performing abiotic synthetic transformations in live cell environments represents a new, promising approach to interrogate and manipulate biology and to uncover new types of biomedical tools. We now found that photocatalytic bond-forming reactions can be added to the toolbox of bioorthogonal synthetic chemistry. Specifically, we demonstrate that exogenous styryl aryl azides can be converted into indoles inside living mammalian cells under photocatalytic conditions.

SUBMITTER: D'Avino C

PROVIDER: S-EPMC10859955 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Intracellular Synthesis of Indoles Enabled by Visible-Light Photocatalysis.

D'Avino Cinzia C Gutiérrez Sara S Feldhaus Max J MJ Tomás-Gamasa María M Mascareñas José Luis JL

Journal of the American Chemical Society 20240126 5

Performing abiotic synthetic transformations in live cell environments represents a new, promising approach to interrogate and manipulate biology and to uncover new types of biomedical tools. We now found that photocatalytic bond-forming reactions can be added to the toolbox of bioorthogonal synthetic chemistry. Specifically, we demonstrate that exogenous styryl aryl azides can be converted into indoles inside living mammalian cells under photocatalytic conditions. ...[more]

PMID: 38277674

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