Ontology highlight
ABSTRACT:
SUBMITTER: Su L
PROVIDER: S-EPMC7443334 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20200823
Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) has been widely spread in the world with a high mortality. Cytokine storm syndrome (CSS) and acute lung injury caused by SARS-CoV-2 infection severely threaten the patients. With the purpose to find effective and low-toxic drugs to mitigate CSS, entecavir and imipenem were identified to reduce TNF-α using a LPS-induced macrophage model from the anti-infective drug library. Entecavir and im ...[more]