Ontology highlight
ABSTRACT:
SUBMITTER: Buschbeck M
PROVIDER: S-EPMC1299226 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Buschbeck Marcus M Hofbauer Sebastian S Di Croce Luciano L Keri Gyorgy G Ullrich Axel A
EMBO reports 20050101 1
It is well established that the mitogen-activated protein kinase (MAPK) signal is regulated through phosphorylation-dependent activation by the three-tiered MAPK cascade. However, our studies on the interaction of the MAPK ERK5 with the tyrosine kinase c-Abl and its oncogenic variants v-Abl and Bcr/Abl disclosed an alternative aspect of regulation. Independent of the MAPK cascade, Abl kinases were able to regulate the cellular amount of ERK5, at least in part, by stabilizing the protein. The res ...[more]