Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi T
PROVIDER: S-EPMC1347031 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20060201 3
h-prune, which has been suggested to be involved in cell migration, was identified as a glycogen synthase kinase 3 (GSK-3)-binding protein. Treatment of cultured cells with GSK-3 inhibitors or small interfering RNA (siRNA) for GSK-3 and h-prune inhibited their motility. The kinase activity of GSK-3 was required for the interaction of GSK-3 with h-prune. h-prune was localized to focal adhesions, and the siRNA for GSK-3 or h-prune delayed the disassembly of paxillin. The tyrosine phosphorylation o ...[more]