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The Vibrio harveyi GTPase CgtAV is essential and is associated with the 50S ribosomal subunit.

ABSTRACT: It was previously reported that unlike the other obg/cgtA GTPases, the Vibrio harveyi cgtAV is not essential. Here we show that cgtAV was not disrupted in these studies and is, in fact, essential for viability. Depletion of CgtAV did not result in cell elongation. CgtAV is associated with the large ribosomal particle. In light of our results, we predict that the V. harveyi CgtAV protein plays a similar essential role to that seen for Obg/CgtA proteins in other bacteria.

SUBMITTER: Sikora AE

PROVIDER: S-EPMC1347350 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature

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The Vibrio harveyi GTPase CgtAV is essential and is associated with the 50S ribosomal subunit.

Sikora A E AE Zielke R R Datta K K Maddock J R JR

Journal of bacteriology 20060201 3

It was previously reported that unlike the other obg/cgtA GTPases, the Vibrio harveyi cgtAV is not essential. Here we show that cgtAV was not disrupted in these studies and is, in fact, essential for viability. Depletion of CgtAV did not result in cell elongation. CgtAV is associated with the large ribosomal particle. In light of our results, we predict that the V. harveyi CgtAV protein plays a similar essential role to that seen for Obg/CgtA proteins in other bacteria. ...[more]

PMID: 16428430

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