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Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.

ABSTRACT: Deregulation of energy metabolism by external interventions or mutations in metabolic genes can extend lifespan in a wide range of species. We describe mutations in Drosophila melanogaster that confer resistance to oxidative stress and display a longevity phenotype. These phenotypes are associated with molecular lesions in a hitherto uncharacterized gene we named Enigma. We show that Enigma encodes a mitochondrial protein with homology to enzymes of the beta-oxidation of fatty acids and that mutations in this locus affect lipid homeostasis. Our analysis provides further support to the notion that lipid metabolism may play a central role in metazoan lifespan regulation.

SUBMITTER: Mourikis P

PROVIDER: S-EPMC1360589 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature

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Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.

Mourikis Philippos P Hurlbut Gregory D GD Artavanis-Tsakonas Spyros S

Proceedings of the National Academy of Sciences of the United States of America 20060124 5

Deregulation of energy metabolism by external interventions or mutations in metabolic genes can extend lifespan in a wide range of species. We describe mutations in Drosophila melanogaster that confer resistance to oxidative stress and display a longevity phenotype. These phenotypes are associated with molecular lesions in a hitherto uncharacterized gene we named Enigma. We show that Enigma encodes a mitochondrial protein with homology to enzymes of the beta-oxidation of fatty acids and that mut ...[more]

PMID: 16434470

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