Discovery of the neutralizing epitope common to influenza B virus victoria group isolates in Japan.

ABSTRACT: Monoclonal antibody 9B2 possesses hemagglutination inhibition activity against all the 2002/2003 influenza B virus Victoria group isolates in Kobe, Japan, as well as representative strains isolated between 1987 and 1997. The 9B2 epitope localizes three-dimensionally in the vicinity of antigenic site A of the hemagglutinin molecule, and amino acid substitutions in this region affected the binding of 9B2.

SUBMITTER: Nakagawa N 

PROVIDER: S-EPMC1448616 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature