Ontology highlight
ABSTRACT:
SUBMITTER: Zhang SL
PROVIDER: S-EPMC1482614 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Zhang Shenyuan L SL Yeromin Andriy V AV Zhang Xiang H-F XH Yu Ying Y Safrina Olga O Penna Aubin A Roos Jack J Stauderman Kenneth A KA Cahalan Michael D MD
Proceedings of the National Academy of Sciences of the United States of America 20060602 24
Recent studies by our group and others demonstrated a required and conserved role of Stim in store-operated Ca(2+) influx and Ca(2+) release-activated Ca(2+) (CRAC) channel activity. By using an unbiased genome-wide RNA interference screen in Drosophila S2 cells, we now identify 75 hits that strongly inhibited Ca(2+) influx upon store emptying by thapsigargin. Among these hits are 11 predicted transmembrane proteins, including Stim, and one, olf186-F, that upon RNA interference-mediated knockdow ...[more]