Ontology highlight
ABSTRACT:
SUBMITTER: Schrick JJ
PROVIDER: S-EPMC1606550 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Schrick Jeffrey J JJ Vogel Peter P Abuin Alejandro A Hampton Billy B Rice Dennis S DS
The American journal of pathology 20060401 4
ADP-ribosylation factor-like 3 (Arl3) is a member of a small subfamily of G-proteins involved in membrane-associated vesicular and intracellular trafficking processes. Genetic studies in Leishmania have shown that the Arl3 homolog is essential for flagellum biogenesis. Mutations in a related human family member, Arl6, result in Bardet-Biedl syndrome in humans, which is characterized by genital, renal, and retinal abnormalities, obesity, and learning deficits. As part of our large-scale phenotypi ...[more]