Ontology highlight
ABSTRACT:
SUBMITTER: Volik S
PROVIDER: S-EPMC164650 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Volik Stanislav S Zhao Shaying S Chin Koei K Brebner John H JH Herndon David R DR Tao Quanzhou Q Kowbel David D Huang Guiqing G Lapuk Anna A Kuo Wen-Lin WL Magrane Gregg G De Jong Pieter P Gray Joe W JW Collins Colin C
Proceedings of the National Academy of Sciences of the United States of America 20030604 13
Genome rearrangements are important in evolution, cancer, and other diseases. Precise mapping of the rearrangements is essential for identification of the involved genes, and many techniques have been developed for this purpose. We show here that end-sequence profiling (ESP) is particularly well suited to this purpose. ESP is accomplished by constructing a bacterial artificial chromosome (BAC) library from a test genome, measuring BAC end sequences, and mapping end-sequence pairs onto the normal ...[more]