Ontology highlight
ABSTRACT:
SUBMITTER: Nakayama K
PROVIDER: S-EPMC1693732 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Nakayama Kentaro K Nakayama Naomi N Davidson Ben B Sheu Jim J-C JJ Jinawath Natini N Santillan Antonio A Salani Ritu R Bristow Robert E RE Morin Patrice J PJ Kurman Robert J RJ Wang Tian-Li TL Shih Ie-Ming IeM
Proceedings of the National Academy of Sciences of the United States of America 20061127 49
Recent studies have suggested an oncogenic role of the BTB/POZ-domain genes in hematopoietic malignancy. The aim of this study is to identify and characterize BTB/POZ-domain genes in the development of human epithelial cancers, i.e., carcinomas. In this study, we focused on ovarian carcinoma and analyzed gene expression levels using the serial analysis of gene expression (SAGE) data in all 130 deduced BTB/POZ genes. Our analysis reveals that NAC-1 is significantly overexpressed in ovarian serous ...[more]